AG Herman

Die Herman-Gruppe will die physiologischen und molekularen Grundlagen der synaptischen Vielfalt verstehen. Insbesondere vergleichen wir zelluläre Prozesse, die in glutamatergen und GABAergen Synapsen ablaufen - den grundlegenden Einheiten, die das Gleichgewicht zwischen Erregung und Hemmung in neuronalen Netzwerken im ZNS steuern. Die Gruppe verwendet eine Kombination aus Elektrophysiologie, Molekularbiologie und Live-Imaging-Techniken, um dieses Thema zu untersuchen.

Ausgewählte Publikationen

Orlando M, Schmitz D, Rosenmund C, Herman MA (2019) Calcium-independent exo-endocytosis coupling at small central synapses. Cell Reports: doi.org/10.1016/jcelrep.2019.11.060

Herman MA [corresponding author], Trimbuch T, Rosenmund C (2018) Differential pH dynamics in synaptic vesicles from intact glutamatergic and GABAergic synapses. Front Synaptic Neurosci: 10:44. doi: 10.3389/fnsyn.2018.00044

Zimmermann J*, Herman MA* [co-first author], Rosenmund C (2015) Co-release of glutamate and GABA from single vesicles in GABAergic neurons exogenously expressing VGLUT3. Front Synaptic Neurosci 7:16 doi:10.3389/fsyn.2015.00016

Herman MA, Ackermann F, Trimbuch T, Rosenmund C (2014) Vesicular glutamate transporter expression level affects release probability. J Neurosci 34:11781-11791

Chang C-L, Trimbuch T, Chao H-T, Jordan J-C, Herman MA [co-corresponding author], Rosenmund C (2014) Investigation of synapse formation and function in a glutamatergic-GABAergic two-neuron microcircuit. J Neurosci 34:855-868

Herman MA* [co-first author], Nahir B*, Jahr CE (2011) Distribution of extracellular glutamate in neuropil of hippocampus. PLoS ONE 6:e26501

Herman MA, Jahr CE (2007) Extracellular glutamate concentration in hippocampal slice. J Neurosci 27:9763

Aktuell

• 2021-2023      NeuroCure Postdoctoral Fellowship for Female Neuroscientists, awarded by NeuroCure Cluster for Excellence, Berlin, Germany

• 2023-2026      Independent Research Project; “Specific mechanisms of neurotransmission in excitatory and inhibitory synapses,” (HE 7480/3-1); awarded by the Deutsches Forschungsgemeinschaft, Germany

Abgeschlossen

• 2016-2020      Independent Research Project, Principal Investigator Position; “Investigation of divergent vesicle recycling mechanisms in glutamatergic and GABAergic synapses,” (HE 7480/2-1); awarded by the Deutsches Forschungsgemeinschaft, Germany

• 2011-2013      Postdoctoral Stipend; “Investigation of VGLUT copy number on vesicle release probability;” awarded by the Alexander von Humboldt Foundation, Germany

• 2006-2010      Predoctoral Ruth L. Kirschstein National Research Service Award; “EAAT3 contribution to glutamate uptake in the hippocampus,” (F31NS057865); awarded by the National Institutes of Health, USA