AG Owald

Group Members

• Isabella Balles (PhD student)
• Dr. Anatoli Ender (Postdoc)
• Tania Fernández del Valle (PhD)
• Marcel Heim (PhD)
• Dr. Sridhar Jagannathan (Postdoc)
• Dr. Niccolò Pampaloni (Postdoc)
• Dr. Carlotta Pribbenow (MD student)
• Dr. Davide Raccuglia (Postdoc)
• Silas Reubold (Technician & Administration)
• Dr. Eric William Reynolds (Postdoc)

Übersicht der Publikation in der Forschungsdatenbank der Charité

2025

Raccuglia, D., Suárez-Grimalt, R., Krumm, L., Ender, A., Brodersen, C. B., Jagannathan, S. R., Freire Krück, M., Pampaloni, N. P., Rauch, C., Winter, Y., Yvon-Durocher, G., Kempter, R., Geiger, J. R. P., & Owald, D. (2025). Network synchrony creates neural filters promoting quiescence in Drosophila. Nature, 646(8085), 667–675. https://doi.org/10.1038/s41586-025-09376-2

Töfflinger, E. V., Makridis, K. L., Heim, M. M., Owald, D., & Kaindl, A. M. (2025). Drosophila melanogaster as a rapid in vivo assay system for preclinical anti-seizure medication testing. Epilepsia open, 10(4), 1260–1267. https://doi.org/10.1002/epi4.70101

Amin, F., Stone, J. T., König, C., Mancini, N., Murakami, K., Bidaye, S. S., Heim, M. M., Owald, D., Majumder, U., Grunwald Kadow, I. C., Pierzchlińska, A., Litwin-Kumar, A., Barnstedt, O., & Gerber, B. (2025). Avoidance engages dopaminergic punishment in Drosophila. bioRxiv : the preprint server for biology, 2025.07.07.663268. https://doi.org/10.1101/2025.07.07.663268
 

2024

Cazalé-Debat, L., Scheunemann, L., Day, M., Fernandez-D V Alquicira, T., Dimtsi, A., Zhang, Y., Blackburn, L. A., Ballardini, C., Greenin-Whitehead, K., Reynolds, E., Lin, A. C., Owald, D., & Rezaval, C. (2024). Mating proximity blinds threat perception. Nature, 634(8034), 635–643. https://doi.org/10.1038/s41586-024-07890-3

Spanagel, R., Bach, P., Banaschewski, T., Beck, A., Bermpohl, F., Bernardi, R. E., Beste, C., Deserno, L., Durstewitz, D., Ebner-Priemer, U., Endrass, T., Ersche, K. D., Feld, G., Gerchen, M. F., Gerlach, B., Goschke, T., Hansson, A. C., Heim, C., Kiebel, S., Kiefer, F., Kirsch, P., Kirschbaum, C., Koppe, G., Lenz, B., Liu, S., Marxen, M., Meinhardt, M.W., Meyer-Lindenberg, A., Montag, C., Müller, C.P., Nagel, W.E., Oliveria, A.M.M., Owald, D., Pilhatsch, M., Priller, J., Rapp, M.A., Reichert, M., Ripke, S., Ritter, K., Romanczuk-Seiferth, N., Schlagenhauf, F., Schwarz, E., Schwöbel, S., Smolka, M.N., Soekadar, S.R., Sommer, W.H., Stock, A.K., Ströhle, A., Tost, H., Vollstädt-Klein, S., Walter, H., Waschke, T., Witt, S.H., Heinz, A; Other members of the ReCoDe Consortium (2024). The ReCoDe addiction research consortium: Losing and regaining control over drug intake-Findings and future perspectives. Addiction biology, 29(7), e13419. https://doi.org/10.1111/adb.13419

Pribbenow, C., & Owald, D. (2024). Skewing information flow through pre- and postsynaptic plasticity in the mushroom bodies of Drosophila. Learning & memory (Cold Spring Harbor, N.Y.), 31(5), a053919. https://doi.org/10.1101/lm.053919.124

Fernandez Lahore, R. G., Pampaloni, N. P., Schiewer, E., Heim, M. M., Tillert, L., Vierock, J., Oppermann, J., Walther, J., Schmitz, D., Owald, D., Plested, A. J. R., Rost, B. R., & Hegemann, P. (2024). Author Correction: Calcium-permeable channelrhodopsins for the photocontrol of calcium signalling. Nature communications, 15(1), 3958. https://doi.org/10.1038/s41467-024-48356-4

2022

Pribbenow, C., Chen, Y. C., Heim, M. M., Laber, D., Reubold, S., Reynolds, E., Balles, I., Fernández-D V Alquicira, T., Suárez-Grimalt, R., Scheunemann, L., Rauch, C., Matkovic, T., Rösner, J., Lichtner, G., Jagannathan, S. R., & Owald, D. (2022). Postsynaptic plasticity of cholinergic synapses underlies the induction and expression of appetitive and familiarity memories in Drosophila. eLife, 11, e80445. https://doi.org/10.7554/eLife.80445

Fernandez Lahore, R. G., Pampaloni, N. P., Schiewer, E., Heim, M. M., Tillert, L., Vierock, J., Oppermann, J., Walther, J., Schmitz, D., Owald, D., Plested, A. J. R., Rost, B. R., & Hegemann, P. (2022). Calcium-permeable channelrhodopsins for the photocontrol of calcium signalling. Nature communications, 13(1), 7844. https://doi.org/10.1038/s41467-022-35373-4

Davide Raccuglia, Raquel Suárez-Grimalt, Laura Krumm, Cedric B Brodersen, Anatoli Ender, Sridhar R. Jagannathan, York Winter, Genevieve Yvon-Durocher, Richard Kempter, Jörg RP Geiger, David Owald. (2022) Coherent multi-level network oscillations create neural filters to favor quiescence over navigation in Drosophila. bioRxiv .03.11.483976; doi: https://doi.org/10.1101/2022.03.11.483976

Vafidis, P., Owald, D., D'Albis, T., & Kempter, R. (2022). Learning accurate path integration in ring attractor models of the head direction system. eLife, 11, e69841. https://doi.org/10.7554/eLife.69841

2021

Carlotta Pribbenow, Yi-chun Chen, Michael-Marcel Heim, Desiree Laber, Silas Reubold, Eric Reynolds, Isabella Balles, Raquel Suárez Grimalt, Carolin Rauch, Jörg Rösner, Gregor Lichtner, Sridhar R. Jagannathan, Tania Fernández-d.V. Alquicira, David Owald. (2021) Postsynaptic plasticity of cholinergic synapses underlies the induction and expression of appetitive memories in Drosophila. bioRxiv 07.01.450776; doi: https://doi.org/10.1101/2021.07.01.450776

2019

Raccuglia D, Huang S, Ender A, Heim MM, Laber D, Suárez-Grimalt R, Liotta A, Sigrist SJ, Geiger JRP, Owald D. (2019) Network-Specific Synchronization of Electrical Slow-Wave Oscillations Regulates Sleep Drive in Drosophila.  Curr Biol. Nov 4;29(21):3611-3621.e3. doi: 10.1016/j.cub.2019.08.070. Epub 2019 Oct 17.PMID: 31630955 

Böhme MA, McCarthy AW, Grasskamp AT, Beuschel CB, Goel P, Jusyte M, Laber D, Huang S, Rey U, Petzoldt AG, Lehmann M, Göttfert F, Haghighi P, Hell SW, Owald D, Dickman D, Sigrist SJ, Walter AM. (2019) Rapid active zone remodeling consolidates presynaptic potentiation. Nat Commun. Mar 6;10(1):1085. doi: 10.1038/s41467-019-08977-6.PMID: 30842428 

2017

Ehmann N, Owald D, Kittel RJ (2017). Drosophila active zones: From molecules to behaviour. Neurosci Res. S0168-0102(17)30662-4

Reddy-Alla S, Böhme MA, Reynolds E, Beis C, Grasskamp AT, Mampell MM, Maglione M, Jusyte M, Rey U, Babikir H, McCarthy AW, Quentin C, Matkovic T, Bergeron DD, Mushtaq Z, Göttfert F, Owald D, Mielke T, Hell SW, Sigrist SJ, Walter AM (2017). Stable positioning of Unc13 restricts synaptic vesicle fusion to defined release sites to promote synchronous neurotransmission. Neuron 95, 1350-1364

2016

Perisse E*, Owald D*, Barnstedt O, Talbot CB, Huetteroth W, Waddell S (2016). Aversive learning and appetitive motivation toggle feed-forward inhibition in the Drosophila mushroom body. Neuron 90, 1086-99, *equal contribution

Patton BR, Burke D, Owald D, Gould T, Bewersdorf J, Booth MJ (2016). Three- dimensional STED microscopy of aberrating tissue using dual adaptive optics. Optics Express 24, 8862-76

Barnstedt O, Owald D**, Felsenberg J, Brain R, Moszynski JP, Talbot CB, Perrat PN, Waddell S** (2016). Memory-relevant mushroom body output synapses are cholinergic. Neuron 89, 1237-47, **co-corresponding author

2015

Owald D, Waddell S (2015). Olfactory learning skews mushroom body output pathways to steer behavioral choice in Drosophila. Curr Opin Neurobiol 35, 178-184

Owald D, Lin S, Waddell S (2015). Light, heat, action: neural control of fruit fly behaviour. Philosophical Transactions B 370, 20140211

Owald D, Felsenberg J, Talbot CB, Das G, Perisse E, Huetteroth W, Waddell S (2015). Activity of defined mushroom body output neurons underlies learned olfactory behavior in Drosophila. Neuron 86, 417-27. Also see Preview by Hige T and Turner G (2015), Neuron 86, 343-5

2014

Lin S, Owald D, Chandra V, Talbot C, Huetteroth W, Waddell S (2014). Neural correlates of water reward in thirsty Drosophila. Nature Neuroscience 17, 1536-42

2013

Matkovic T, Siebert M, Knoche E, Depner H, Mertel S, Owald D, Schmidt M, Thomas U, Sickmann A, Kamin D, Hell SW, Bürger J, Hollmann C, Mielke T, Wichmann C, Sigrist SJ (2013). The Bruchpilot cytomatrix determines the size of the readily releasable pool of synaptic vesicles. J Cell Biol 202, 667-83

2012

Burke CJ*, Huetteroth W*, Owald D, Perisse E, Krashes MJ, Das G, Gohl D, Silies M, Certel S, Waddell S (2012). Layered reward signaling through octopamine and dopamine in Drosophila. Nature 492, 433-7, *equal contribution

Owald D*, Khorramshahi O*, Gupta VK*, Banovic D, Depner H, Fouquet W, Wichmann C, Mertel S, Eimer S, Reynolds E, Holt M, Aberle H, Sigrist SJ (2012). Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic assembly. Nature Neuroscience 15, 1219-26, *equal contribution

2011

Christiansen F, Zube C, Andlauer T, Wichmann C, Fouquet W, Owald D, Mertel S, Leiss F, Tavosanis G, Farca Luna A, Fiala A, Sigrist SJ (2011). Presynapses in Kenyon cell dendrites in the mushroom body calyx of Drosophila. J Neuroscience 31, 9696-707

2010

Hallermann S, Kittel RJ, Wichmann C, Weyhersmüller A, Fouquet W, Mertel S, Owald D, Eimer S, Depner H, Schwärzel M, Sigrist SJ, Heckmann M (2010). Naked dense bodies provoke depression. J Neuroscience 30, 14340-45

Banovic D*, Khorramshahi O*, Owald D, Wichmann C, Riedt T, Tian R, Sigrist SJ, Aberle H (2010). Drosophila Neuroligin 1 coordinates pre- and postsynaptic assembly. Neuron 66, 724-38, *equal contribution

Owald D*, Fouquet W*, Schmidt M, Wichmann C, Mertel S, Depner H, Christiansen F, Zube C, Quentin C, Korner J, Urlaub H, Mechtler K, Sigrist SJ (2010). A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila. J Cell Biol 188, 565-79, *equal contribution

2009

Fouquet W*, Owald D*, Wichmann C, Mertel S, Depner H, Dyba M, Hallermann S, Kittel RJ, Eimer S, Sigrist SJ (2009). Maturation of active zone assembly by Drosophila Bruchpilot. J Cell Biol 186, 129-45, * equal contribution.

Owald D and Sigrist SJ (2009). Assembling the presynaptic active zone. Curr Opin Neurobiol 19, 311-318.