Researchgroup Kovács - Mitochondrial Physiology and Pathophysiology in CNS

Research Focus

  • Activity dependent changes in neuronal energy metabolism
  • Contribution of free radical dependent mechanisms to abnormal network synchronization in epilepsy and schizophrenia
  • Alterations of neurometabolic and neurovascular coupling during recurrent seizure activity
  • Mechanisms of pharmacoresistance in temporal lobe epilepsy

Methods

Combined electrophysiological and live cell imaging applications by using

     Whole cell patch clamp recordings
     Local field potential, oxygen and ion-sensitive electrode recordings
     Laser-scanning and multiphoton confocal microscopy
     Post hoc immunofluorescence labeling and reconstruction

In vitro models of epilepsy/gamma oscillations/microvasculature by using acute brain slices and slice cultures

Funding

Recent

Deutsche Forschungsgemeinschaft KO3814/1-1, “Vulnerability of inhibitory basket cells to oxidative stress during maturation and its impact on schizophrenia and epilepsy”

Past

2002–2004, Confirming the International Role of Community Research, INCO 2, Strategic action on Training and Excellence, (ICA1-CT-2002-70007/8)

2008-2012, Deutsche Forschungsgemeinschaft, SFB TR3 Project D12

Group Members

MD and PhD Students:

Luisa Hasam Henderson

Grace Gotti

 

Alumni:

Dr. Alex Rabanus

Dr. Nando Taubenberger

Dr. Christine Huchzermeyer

Dr. Dániel Járdánházy-Kurutz

Dr. Anna Wójtowicz

Dr. Seda Salar

Kristin Lehmann

Jutta Swolinsky

Simon Jacobi

Hannes Riemenschneider

Bifeng Wu

Publications

(All publications available on Opens external link in current windowResearchGate)

Selected:

1.        Liotta A, Rösner J, Huchzermeyer C, Wojtowicz A, Kann O, Schmitz D, Heinemann U, Kovács R (2012) Energy demand of synaptic transmission at the hippocampal Schaffer-collateral synapse J Cerebral Blood Flow and Metabolism, 32(11):2076-83.

2.           Kann O, Taubenberger N, Huchzermeyer C, Papageorgiou IE, Benninger F, Heinemann U, Kovács R. (2012) Muscarinic receptor activation determines the effects of store-operated Ca2+-entry on excitability and energy metabolism in pyramidal neurons. Cell Calcium. 51(1):40-50.

3.           Kovács R, Alexander R, Otáhal J, Patzak R, Kardos J, Albus K, Heinemann U, Kann O (2009) Endogenous nitric oxide is a key promoting factor for initiation of seizure-like events in hippocampal and entorhinal cortex slices. J Neurosci. 29(26):8565-77.

4.           Kovács R, Kardos J, Heinemann U, Kann O. (2005) Mitochondrial calcium ion and membrane potential transients follow the pattern of epileptiform discharges in hippocampal slice cultures. J Neurosci. 25:4260-4269

5.           Kovács R, Schuchmann S, Gabriel S, Kann O, Kardos J, Heinemann U. (2002) Free radical-mediated cell damage after experimental status epilepticus in hippocampal slice cultures. J Neurophys. 88:2909-2918 Impact Factor 3.04