Research group Gerevich

Research focus

  • Physiology and pathophysiology of cortical network activity
  • Modulation and pharmacology of gamma oscillations
  • Physiology, pathophysiology and pharmacology of purinergic signalling in the nervous system
  • Purinergic receptors and network activity


  • Electrophysiology (Patch clamp, local field potential)
  • Spinning disc confocal microscopy
  • Fluorescence imaging techniques
  • Acute brain slices


  • Christoph Kulisch
  • Zin-Juan Klaft
  • Helena Stengl

Selected publications

Schulz SB, Heidmann KE, Mike A, Klaft ZJ, Heinemann U, Gerevich Z (2012) First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors. Br J Pharmacol. 167(7):1480-91.

Klaft ZJ, Schulz SB, Maslarova A, Gabriel S, Heinemann U, Gerevich Z (2012) Extracellular ATP differentially affects epileptiform activity via purinergic P2X7 and adenosine A(1) receptors in naive and chronic epileptic rats. Epilepsia. 53:1978-86.

Schulz SB, Klaft ZJ, Rösler AR, Heinemann U, Gerevich Z (2012) Purinergic P2X, P2Y and adenosine receptors differentially modulate hippocampal gamma oscillations. Neuropharmacology. 62:914-24.

Guzman SJ, Schmidt H, Franke H, Krügel U, Eilers J, Illes P, Gerevich Z (2010) P2Y1 receptors inhibit long-term depression in the prefrontal cortex. Neuropharmacology. 59:406-15.

Stanchev D, Blosa M, Milius D, Gerevich Z, Rubini P, Schmalzing G, Eschrich K, Schaefer M, Wirkner K, Illes P (2009) Cross-inhibition between native and recombinant TRPV1 and P2X(3) receptors. Pain. 143:26-36.

Köles L, Gerevich Z, Oliveira JF, Zadori ZS, Wirkner K, Illes P (2008) Interaction of P2 purinergic receptors with cellular macromolecules. Naunyn Schmiedebergs Arch Pharmacol. 377:1-33

Karoly R, Mike A, Illes P, Gerevich Z (2008) The unusual state-dependent affinity of P2X3 receptors can be explained by an allosteric two-open-state model. Mol Pharmacol. 73:224-34. Szasz BK, Mike A, Karoly R, Gerevich Z, Illes P, Vizi ES, Kiss JP (2007) Direct inhibitory effect of fluoxetine on N-methyl-D-aspartate receptors in the central nervous system. Biol Psychiatry. 62:1303-9.

Gerevich Z, Zadori ZS, Köles L, Kopp L, Milius D, Wirkner K, Gyires K, Illes P (2007) Dual effect of acid pH on purinergic P2X3 receptors depends on the histidine 206 residue. J Biol Chem. 282:33949-57

Gerevich Z, Zadori Z, Müller C, Wirkner K, Schröder W, Rubini P, Illes P (2007) Metabotropic P2Y receptors inhibit P2X3 receptor-channels via G protein-dependent facilitation of their desensitization. Br J Pharmacol. 151:226-36.

Hausmann R, Rettinger J, Gerevich Z, Meis S, Kassack MU, Illes P, Lambrecht G, Schmalzing G (2006) The suramin analog 4,4',4'',4'''-(carbonylbis(imino-5,1,3-benzenetriylbis (carbonylimino)))tetra-kis-benzenesulfonic acid (NF110) potently blocks P2X3 receptors: subtype selectivity is determined by location of sulfonic acid groups. Mol Pharmacol. 69:2058-67.15

Gerevich Z, Müller C, Illes P (2005) Metabotropic P2Y1 receptors inhibit P2X3 receptor-channels in rat dorsal root ganglion neurons. Eur J Pharmacol. 521:34-8.

Guzman SJ, Gerevich Z, Hengstler JG, Illes P, Kleemann W (2005) P2Y1 receptors inhibit both strength and plasticity of glutamatergic synaptic neurotransmission in the rat prefrontal cortex. Synapse. 57:235-8.

Gerevich Z, Illes P (2004) P2Y receptors and pain transmission. Purinergic Signal. 1:3-10.

Wirkner K, Gerevich Z, Krause T, Günther A, Köles L, Schneider D, Nörenberg W, Illes P (2004) Adenosine A2A receptor-induced inhibition of NMDA and GABAA receptor-mediated synaptic currents in a subpopulation of rat striatal neurons. Neuropharmacology 46:994-1007.

Gerevich Z, Borvendeg SJ, Schröder W, Franke H, Wirkner K, Nörenberg W, Fürst S, Gillen C, Illes P. Inhibition of N-type voltage-activated calcium channels in rat dorsal root ganglion neurons by P2Y receptors is a possible mechanism of ADP-induced analgesia. J Neurosci. 24:797-807.

Wirkner K, Schweigel J, Gerevich Z, Franke H, Allgaier C, Barsoumian EL, Draheim H, Illes P (2004) Adenine nucleotides inhibit recombinant N-type calcium channels via G protein-coupled mechanisms in HEK 293 cells; involvement of the P2Y13 receptor-type. Br J Pharmacol. 141:141-51.

Wirkner K, Assmann H, Köles L, Gerevich Z, Franke H, Nörenberg W, Boehm R, Illes P (2000) Inhibition by adenosine A(2A) receptors of NMDA but not AMPA currents in rat neostriatal neurons. Br J Pharmacol. 130:259-69.

Group leader

PD Dr. med. Zoltan Gerevich

Research group leader

Charité - Universitätsmedizin Berlin

CCM: Campus Charité Mitte

Charité Center Basic Sciences CC 2

Institute of Neurophysiology

RG Gerevich

Postal address:

Charitéplatz 1

10117 Berlin

Internal address:

Virchowweg 6

t: +49 30 450 528 155 / +49 450 528 359

f: +49 30 450 539 950