Madry group

Microglia physiology in health and disease

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Head of the research group

Dr. rer. nat. Christian Madry

CCM: Campus Charité Mitte

Dr. Christian Madry
Foto CM/Charité

Research focus

Images of a mouse hippocampal microglia captured at a single time point (left), and cumulatively over 20 minutes (right), show how it constantly surveys its environment (scale bar: 20 µm).
Foto: CM/UCL London
Images of a mouse hippocampal microglia captured at a single time point (left), and cumulatively over 20 minutes (right), show how it constantly surveys its environment (scale bar: 20 µm). Foto: CM/UCL London

My research interest focuses on the physiology of microglia, the innate immune cells in the brain. In particular I am interested in the functional roles of receptors and ion channels of microglia, both in physiology and pathology. Due to their enormous pathological potential my current and future research focuses on the importance of microglia-mediated mechanisms for the pathogenesis of neurodegenerative diseases.

Microglia continuously survey the brain to detect infection or cell damage, remove dying neurons and prune synapses during development. We have recently shown that microglial immune surveillance and interleukin-1β release are regulated by the K+ channel THIK-1.

Methods

  • Patch-clamp electrophysiology of microglial cells in brain slices
  • Two-photon and confocal microscopy
  • Molecular biology

Group member

Bilal Baroud (Master student)

Ali Rifat (MD student)

Michael Surala (PhD student)

Publication list

Publications via the Research Data Base Charité

Selected publications:

Izquierdo P, Attwell D, Madry C (2019)Ion channels and receptors as determinants of microglial function. Trends Neurosci. 42(4), 278-292 PubMed

Madry C, Kyrargyri V, Hamilton-Whitaker N, Arancibia-Carcamo I, Chan V and Attwell D. (2018)
Effects of the ecto-ATPase apyrase on microglial ramification and surveillance reflect cell depolarization not ATP depletion. Proc Natl Acad Sci U S A doi: 10.1073/pnas.1715354115. PubMed

Madry C, Jolivet R, Kyrargyri V, Arancibia-Carcamo I, Kohsaka S and Attwell D. (2017)
Microglial motility and interleukin-1β release are regulated by the K+ channel THIK-1
Neuron 97(2), 299-312. PubMed

Madry C and Attwell D. (2015)
Receptors, ion channels and signaling mechanisms underlying microglial dynamics.
J Biol Chem 290(20):12443-12450. PubMed

Madry C, Haglerod C and Attwell D. (2010)The role of pannexin hemichannels in the anoxic depolarization of hippocampal pyramidal cells. Brain 133(12):3755-3763. PubMed