Gerevich group

The Gerevich lab focuses on gamma oscillations: rhythmic fluctuations of electrical activity in the brain at frequencies of 30-90 Hz. Gamma oscillations play an important role in higher cognitive processes such as attention, sensory processing, learning and memory by supporting neural communication and synaptic plasticity. Their impairments reflect disturbed cortical information processing in neuropsychiatric diseases such as schizophrenia, autism spectrum disorder and Alzheimer’s disease. Our objective is to understand the circuit and synaptic mechanisms of gamma oscillations with the translational goal to find targets in the circuit, which are able to modulate and eventually normalize impaired network activity.

• Circuit and synaptic mechanisms of cortical and hippocampal gamma oscillations
• Pharmacology of gamma oscillations
• Modulation of gamma oscillations
• Pathophysiology of cortical and hippocampal gamma oscillations in neuropsychiatric diseases such as schizophrenia, Alzheimer’s disease and autism spectrum disorder
• Pharmacology of epileptiform activity in the medial temporal lobe
• Physiology, pathophysiology and pharmacology of purinergic signalling in the nervous system
• Involvement of purinergic receptors in network activity

• Patch-clamp technique in acute brain slices
• Extracellular local field potential recordings in vitro
• Intracellular sharp electrode recording
• Immunocytochemistry
• Pharmacological animal models of schizophrenia
• Fluorescence imaging techniques