Gerevich group

Neural oscillations in health and disease

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Head of the research group

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Research focus

Wavelet transform of local field potentials in the CA3 area of a hippocampal slice showing gamma oscillations with a peak frequency of ~40 Hz. Scale bar: 100 ms. Foto: ZG/Charité

The Gerevich lab focuses on gamma oscillations: rhythmic fluctuations of electrical activity in the brain at frequencies of 30-90 Hz. Gamma oscillations play an important role in higher cognitive processes such as attention, sensory processing, learning and memory by supporting neural communication and synaptic plasticity. Their impairments reflect disturbed cortical information processing in neuropsychiatric diseases such as schizophrenia, autism spectrum disorder and Alzheimer’s disease. Our objective is to understand the circuit and synaptic mechanisms of gamma oscillations with the translational goal to find targets in the circuit, which are able to modulate and eventually normalize impaired network activity.

  • Circuit and synaptic mechanisms of cortical and hippocampal gamma oscillations
  • Pharmacology of gamma oscillations
  • Modulation of gamma oscillations
  • Pathophysiology of cortical and hippocampal gamma oscillations in neuropsychiatric diseases such as schizophrenia, Alzheimer’s disease and autism spectrum disorder
  • Pharmacology of epileptiform activity in the medial temporal lobe
  • Physiology, pathophysiology and pharmacology of purinergic signalling in the nervous system
  • Involvement of purinergic receptors in network activity

 

Methods

Double immunofluorescence of purinergic P2X4 receptors (red) and DAPI (4',6-diamidino-2-phenylindole, a DNA marker staining all cell nuclei; green) in the CA3 area of the hippocampus reveals dendritic localization of the receptors on CA3 pyramidal cells. Foto: ZG/Charité

  • Patch-clamp technique in acute brain slices
  • Extracellular local field potential recordings in vitro
  • Intracellular sharp electrode recording
  • Immunocytochemistry
  • Pharmacological animal models of schizophrenia
  • Fluorescence imaging techniques

Team of the Gerevich group

MD/PhD Students:

Luisa Hasam Henderson

Ecem Tütüncü (MD student)

Florian Wildner (MD student)

Alexander Klemz (MD student)

Alumni:

 

Maria Almut Meier

Clément E. Lemercier

Zin-Juan Klaft
Constance Holman
Karin E. Heidmann
Christoph Kulisch
Helena Stengl
Steffen Schulz
Segundo J. Guzman
Laurenz Kopp
Christoph Müller
Robert Karoly
Zoltan S. Zádori

Publication list

Publications via the Research Data Base Charité

Selected publications:

Lemercier CE, Holman C, Gerevich Z (2017) Aberrant alpha and gamma oscillations ex vivo after single application of the NMDA receptor antagonist MK-801. Schizophr Res. 188:118-124. PubMed

Guzman SJ, Gerevich Z (2016) P2Y Receptors in Synaptic Transmission and Plasticity: Therapeutic Potential in Cognitive Dysfunction. Neural Plast. 2016:1207393. PubMed

Lemercier CE, Schulz SB, Heidmann KE, Kovács R, Gerevich Z (2016) Dopamine D3 Receptors Inhibit Hippocampal Gamma Oscillations by Disturbing CA3 Pyramidal Cell Firing Synchrony. Front Pharmacol. 6:297. PubMed

Klaft ZJ, Hollnagel JO, Salar S, Calişkan G, Schulz SB, Schneider UC, Horn P, Koch A, Holtkamp M, Gabriel S, Gerevich Z, Heinemann U. (2016) Adenosine A1 receptor-mediated suppression of carbamazepine-resistant seizure-like events in human neocortical slices. Epilepsia 57:746-56. PubMed

Schulz SB, Heidmann KE, Mike A, Klaft ZJ, Heinemann U, Gerevich Z (2012) First and second generation antipsychotics influence hippocampal gamma oscillations by interactions with 5-HT3 and D3 receptors. Br J Pharmacol. 167(7):1480-91.PubMed