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Glossary

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A

ALS

abbreviation of: Amyotrophic lateral sclerosis

ATMP

abbreviation of: Advanced Therapy Medicinal Product

C

Charité 3R

definition: Charité 3R

Charité 3R – Replace | Reduce | Refine – promotes the development of innovative methods in biomedical research with the objective of replacing animal experiments, reducing their number or refining experiments in order to relieve the burden placed on laboratory animals. With the over-arching goal of improving biomedical translation into applicable therapies for the human patient in mind, Charité 3R is an interdisciplinary effort to improve both medicine and animal welfare. Charité 3R will stimulate research in all 3Rs and consequently foster the development of novel alternative methods.

Charite 3R Website

CT

abbreviation of: computed tomography

D

DFG

abbreviation of: Deutsche Forschungsgemeinschaft

German Research Foundation

C

Calcium-Imaging

definition: Calcium-Imaging: image-based measurement

image-based measurement of neuronal activity based on Ca2+-sensitive fluorescing proteins which change their fluorescence properties based on the amount of intracellular Ca2+.

M

MRI

abbreviation of: Magnetic resonance imaging

N

NMDA-receptors

definition: N-Methyl-D-Aspartate-receptors

membrane-bound ionotropic glutamate receptors, conducting Ca2+ und Na+ ions and thus mediating excitatory communication between neurons

P

PCR

abbreviation of: Polymerase Chain Reaction

Molecular biological procedure to amplify DNA

V

Voltage indicators

definition: Voltage indicators: membrane-bound voltage-sensitive fluorescing proteins

Voltage indicators are genetically encoded membrane-bound voltage-sensitive fluorescing proteins, which change their fluorescence properties based on the membrane potential of a cell.

T

TLE

abbreviation of: temporal lobe epilepsy

temporal lobe epilepsy